Association between genetic polymorphism in DNA repair genes XRCC3 and risks of laryngeal carcinoma
10.16066/j.1672-7002.2016.09.005
- VernacularTitle:X线交叉互补修复基因3遗传变异与喉癌风险的相关性
- Author:
ER·Alimu NILIPA
;
Lingling WANG
;
Bo ZHANG
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
DNA Repair;
Variation (Genetics);
X-ray repair cross-complementing group 3
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(9):511-514
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the association between polymorphism of DNA repair gene XRCC3Thr 241 Met and the risks of developing laryngeal carcinoma. METHODS Sixty patients with laryngeal carcinoma and 120 cancer-free controls were genotyped for the polymorphism by Multiplex SNaPshot.The odds ratios (ORs) and 95% confidence intervals (Cls) were calculated using unconditional logistic regression model.RESULTS The XRCC3 241 Met allele increased the risks of developing laryngeal carcinoma.Comparing with subjects having the XRCC3241 Thr/Thr genotype,the subjects at least having one XRCC3 241 Met allele had OR of 4.27 (95%CI 1.49-12.18). CONCLUSION XRCC3 Thr 241 Met plays an important role in the development of laryngeal carcinoma.
