Noninvasive functional imaging techniques: positron emission tomography (PET), magnetic resonance spectroscopy (MRS), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
- VernacularTitle:非损伤性功能成像技术:正电子发射断层扫描术、磁共振波谱分析和动态对比增强磁共振影像学
- Author:
Ruediger E. Port
- Publication Type:Journal Article
- Keywords:
PET;
in vivo;
MRS;
DCE-MRI
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2007;12(11):1295-1298
- CountryChina
- Language:Chinese
-
Abstract:
In the pharmaceutical industry, there is currently increasing interest in noninvasive functional imaging techniques as potential early indicators of drug effects in patients. PET allows one to monitor absolute concentrations of radiolabeled drugs and metabolites, or of ligands to specific receptors, in tissues, and to visualize their distribution three-dimensionally. MRS is capable of monitoring metabolic conversions in vivo without labeling. DCE-MRI shows the distribution of small-molecular, hydrophilic weight contrast agents between blood plasma and interstitial space in tissue in real time and can be used to detect effects of antivascular or anti-angiogenic compounds.
