Impact of laparoscopic surgical intervention for severe acute pancreatitis on TNF alpha, IL-6 and sIL-2R
10.3969/j.issn.1007-1989.2017.11.015
- VernacularTitle:腹腔镜手术治疗重症急性胰腺炎及对TNF-α、IL-6和sIL-2R水平的影响
- Author:
Wang JUN-FENG
1
;
Li NA
;
Luo QING
Author Information
1. 核工业四一七医院 检验科
- Keywords:
severe acute pancreatitis;
laparoscopic intervention;
TNF-α;
IL-6;
sIL-2R
- From:
China Journal of Endoscopy
2017;23(11):74-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the impact of laparoscopic surgical intervention for severe acute pancreatitis on TNF alpha, IL - 6 and sIL-2R. Methods Take 92 patients with SAP accepted laparoscopic surgical intervention as the research object, they were divided into laparotomy group (46 cases): received traditional open surgery;laparoscopic group (46 cases): received laparoscopic surgery intervention. Then compare the levels of TNF alpha, IL-6 and sIL-2R between the two groups. Results The time of laparoscopy group was (82.21 ± 14.56) min, intraoperative blood loss was (172.23 ± 23.31) mL, total cost was (21512.46 ± 121.35) yuan, which was less than laparotomy group; the cure rate of laparoscopic group was 93.48％ (43/46). It was obviously higher than that in laparotomy group 86.96％ (40/46); The complication rate was 23.91％ (11/46), the death rate 6.52％ (3/46) of laparoscopic group were significantly lower than that in laparotomy group. After laparoscopic surgery, the level of TNF alpha (24.70 ± 6.90) ng/L, IL-6 (18.32 ± 8.91) ng/L and sIL-2R (98.60 ± 8.91) pmol/L was significantly lower than laparotomy group. All the differences compared between the two groups was statistical significant (P < 0.05). Conclusion The laparoscopic intervention for SAP has distinct curative effect. It can effectively reduce the rate of complications and mortality, and improve the cure rate, is deserving popularization and application.
