Changes and Clinical Significance of Melatonin in Blood and Cerebrospinal Fluid of Patients with Parkinson's Disease
10.3969/j.issn.1671-7414.2017.05.024
- VernacularTitle:帕金森病患者血清和脑脊液褪黑素水平变化及其临床意义
- Author:
Qi WU
1
;
Liang CHEN
;
hua Bao ZHANG
Author Information
1. 安康市中医医院急诊科
- Keywords:
parkinson's disease;
melatonin;
serum;
cerebrospinal fluid
- From:
Journal of Modern Laboratory Medicine
2017;32(5):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of melatonin (MLT) in blood and cerebrospinal fluid (CSF) of Parkinson's disease (PD) patient and its clinical significance.Methods 63 PD patients from January 2016 to December 2016 were recruited to participate in the study as PD group.60 patients without nervous system disease were randomly selected in their hospital in the same period of time as the control group.The concentrations of MLT in blood and CSF samples were measured and analyzed.Results The serum and CSF levels of MLT in control group was significantly positively related to age (r=-0.190,P=0.041;r=-0.208,P =0.017).The serum and CSF levels of MLT in PD group were significantly higher than those in control group (87.3±9.2 pg/ml vs 49.5±4.4 pg/ml,t=28.802,P=0.000;338.7±58.6 pg/ml vs 232.8±39.7 pg/ml,t=11.682,P=0.000).The serum and CSF levels of MLT in PD group both were positively correlated with disease course (r=0.207,P=0.004;r=0.145,P=0.013),UPDRS Ⅱ (r=0.187,P=0.013;r=0.192,P=0.007),UPDRS Ⅲ (r =0.156,P=0.033;r=0.196,P=0.018) and H-Y classification (r=0.206,P=0.019;r=0.294,P=0.004).Conclusion MLT in blood and CSF of PD patients increased significantly.And they both positively correlated with disease course and severity.
