Status of AMH in Serum of Healthy Women in Shenzhen Area and Its Value in PCOS and POF Treatment
10.3969/j.issn.1671-7414.2017.05.038
- VernacularTitle:深圳地区健康育龄妇女血清中AMH水平现况及其在PCOS和POF诊疗中的价值
- Author:
Li YUAN
1
;
gang Ming CHENG
;
ping Xiang LIU
;
zhong Yu XU
;
yong Xiao LI
Author Information
1. 深圳市宝安区人民医院检验科
- Keywords:
women of childbearing age;
anti-sapling hormone;
current status;
polycystic ovary syndrome;
premature ovarian failure;
value
- From:
Journal of Modern Laboratory Medicine
2017;32(5):141-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the current status of anti-mullerian hormone (AMH) in healthy women in the healthy childbearing age in Shenzhen area,and to explore its application value in polycystic ovary syndrome (PCOS) and prature ovarian syndrome (POF) treatment.Methods Collected 860 cases of medical health women of childbearing age in Shenzhen BaoanDistrict People's Hospital from January 2016 to March 2017 as control group,and at the same time selected 59 cases of patients with PCOS and 61 cases of patients with POF as observation group.Adopted DXI800 chemiluminescence analyzer to test serum AMH level of control group,patients with PCOS and POF group respectively before and 3 months after treatment,and the testing results were analyzed.Results The serum AMH level of Healthy women of childbearing age was 4.91 ±1.56 ng/ml,18～25 years old group was 5.38±1.27 ng/ml,31～35 and 36～42 years old group were 4.53±1.40 ng/ml and 3.95±1.16 ng/ml,being all lower than that in group 18～25 years old (t=3.082,5.066,all P＜0.05).While 26～30 years old group was 5.09± 1.45 ng/ml,and compared with 18～ 25,there was no statistically significant difference (t=0.892,P＞0.05).Before the treatment,the serum AMH level of PCOS was 10.13± 3.85 ng/ml,significantly higher than the control group,the difference was statistically significant (t=13.924,P＜0.01),while the serum AMH level of POF group and wait POF patients were 1.04±0.37 ng/ml and 2.39±0.87 ng/ml,significantly lower than the control group (t=10.913,8.042,all P＜0.05),and POF lower than wait POF group (t=2.875,P＜0.05).After treatment,the serum AMH level of PCOS was 5.22± 1.58 ng/ml,significantly lower than before treatment (t =11.106,P＜0.05),and there was no statistically significant difference between control group (t=1.036,P＞0.05),the serum AMH level of POF and wait POF were 4.49±1.32 ng/ml and 4.54± 1.47 ng/ml,significantly higher than the before treatment (t=9.608,7.253,all P＜0.05),and compared with the control group there were no statistically significant differences (t =1.209,0.918,all P＞0.05).Conclusion Before the treatment,the serum AMH levels of PCOS were increased significantly,and the serum AMH levels of POF and wait POF patients were significantly reduced,while the serum AMH levels of PCOS,POF and wait POF patients were all restored to normal levels after treatment.Therefore,AMH has certain application value in the diagnosis and treatment evaluation of women PCOS and POF disease.
