Clinical Significance of Detecting miR-126 in Hemodialysis with Coronary Artery Disease

VernacularTitle:miR-126在血液透析并发冠心病患者中检测的临床意义
Author: Abulizi · ADILA ¹ ; Min LIU
Author Information

1. 新疆维吾尔自治区人民医院肾病科
Keywords: hemodialysis; coronary artery disease; miR-126
From: Journal of Modern Laboratory Medicine 2017;32(5):97-99
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance and level changes of miR-126 on hemodialysis patients.Methods 60 cases from hemodialysis were divided into patients with coronary artery disease (35cases),including single coronary artery lesion (12cases) and two coronary artery lesion (13cases) and coronary multivessel lesions (10cases),or no coronary artery disease (25cases).They were detected miR-126 expression by real-time PCR.Results There were obvious differences of miR-126 expression levels between patients and normal group (F=5.32,P＜0.05),and obvious differences of A groups and B groups,or C groups (t=6.32 ～ 8.35,all P＜0.05).Among single coronary artery lesion,two coronary artery lesion,and coronary multivessel lesions,there were obvious differences of miR-126 expression levels (F=6.15,P＜0.05).The single coronary artery lesion had a higher miR-126 expression levels than those of two coronary artery lesion and coronary multivessel lesions (t=8.41～11.65,all P＜0.05).Conclusion Detection of miR-126 expression levels could be related to hemodialysis with coronary artery disease.