Effect of apelin/APJ in retinal vascular diseases
10.3760/cma.j.issn.2095-0160.2017.10.018
- VernacularTitle:Apelin/APJ在视网膜血管性疾病中的作用
- Author:
Li CHEN
1
;
北京市健宫医院眼科
Author Information
1. 100044 北京大学人民医院眼科 视觉损伤与修复教育部重点实验室 视网膜与脉络膜诊断与治疗北京市重点实验室;北京市健宫医院眼科
- Keywords:
Apelin;
APJ;
Retina;
Angiogenesis
- From:
Chinese Journal of Experimental Ophthalmology
2017;35(10):936-939
- CountryChina
- Language:Chinese
-
Abstract:
The G protein-coupled receptor was deorphanized with cloning of the APJ-endogenous ligand apelin,which is an important active peptides.Apelin/APJ system is widely distributed in central nervous system,cardiovascular system,immune system and endocrine system.Therefore,apelin plays important physiological and pathological roles in blood pressure regulation,fluid homeostasis,potent inotropic,insulin sensitivity regulation,pituitary hormone release,human immunodeficiency virus (HIV) entry inhibition,etc.Recently,the studies found apelin/APJ system also regulates the vasculogenesis and angiogenesis of retina through inducing cell proliferation,migration and tube formation in endothelium.The experiments in vivo also demonstrate apelin/APJ system plays a role in physiological and pathological retinal vascular formation.This review summarizes the evidence of apelin in physiological retinal vascular diseases and diabetic retinopathy,retinopathy of prematurity and choroidal neovascular ization.
