Valuation of neutrophil-to-lymphocyte ratio in peripheral blood as a prognostic factor for patients with triple-negative breast cancer
10.3760/cma.j.issn.1673-422X.2017.11.005
- VernacularTitle:外周血中性粒细胞-淋巴细胞比值在三阴性乳腺癌患者预后分析中的价值
- Author:
Yukai PAN
1
Author Information
1. 214400,江苏省江阴市人民医院肿瘤内科
- Keywords:
Breast neoplasms;
Lymphocytes;
Prognosis;
Retrospective studies
- From:
Journal of International Oncology
2017;44(11):824-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features of patients with triple-negative breast cancer (TNBC) and prognostic factors,and to analyze the correlation between neutrophil-to-lymphocyte ratio (NLR) in peripheral blood before operation and the prognosis of TNBC patients and investigate the value of NLR as a prognostic index for patients with TNBC.Methods The clinical data of 87 patients with TNBC treated in People's Hospital of Jiangyin of Jiangsu Province from January 2008 to January 2013 were analyzed retrospectively.The patients were divided into low NLR group (NLR≤4.39,n =58) and high NLR group (NLR ＞4.39,n =29) according to the NLR in peripheral blood before operation.The correlations between NLR and clinic-pathological features were analyzed.Kaplan-Meier method was used to estimate the survival.The univariate analysis was done and Cox proportional hazards regression model was used for multivariate analysis to explore the effect of the NLR in peripheral blood before operation on survival of TNBC patients.Results The high NLR value was related with the clinical stage (x2 =8.628,P =0.005) and lymph node metastasis (x2 =4.911,P =0.027).However,NLR was not correlated with age (x2 =0.575,P =0.448),pathological types (x2 =0.687,P =0.709),tumor size (x2 =3.523,P =0.172),smoking (x2 =0.536,P =0.474),drinking (x2 =0.043,P =0.837) or inheritance (x2 =0.315,P =0.585).Univariate analysis showed that lymph node metastasis (HR =2.02,P =0.021),clinical stage (HR =2.69,P =0.007) and NLR value (HR =2.26,P =0.014) were related to the overall survival of patients with TNBC.Cox multivariate analysis showed that clinical stage (HR =4.10,P =0.033) and NLR value (HR =3.44,P =0.016) were independent predictors of prognosis in patients with TNBC.Conclusion In TNBC,the NLR level is related to clinical tumor stage and lymph node metastasis significantly.Furthermore,the higher NLR value is a novel independent prognostic risk factor,which has important implications on prognosis of patients with TNBC.
