Wnt/β-catenin signaling pathway and cancer stem cells
10.3760/cma.j.issn.1673-422X.2017.11.012
- VernacularTitle:Wnt/β-catenin信号通路与肿瘤干细胞
- Author:
Pei ZHENG
1
Author Information
1. 解放军总医院呼吸科
- Keywords:
Neoplastic stem cells;
Therapy;
Wnt/β-catenin signaling pathway
- From:
Journal of International Oncology
2017;44(11):853-855
- CountryChina
- Language:Chinese
-
Abstract:
Adult stem cells play important roles in the regeneration of human tissues,and they form cancer stem cells when malignant transformation occurs.Cancer stem cells are closely related to the occurrence of various tumors,chemotherapy resistance and recurrence.The Wnt/β-catenin signaling pathway regulates embryonic development and is evolutionarily conserved,and plays an important role in self-renewal and differentiation of cancer stem cells.The Wnt/β-catenin signaling pathway and related regulatory proteins have become a hot target for cancer stem cell targeted therapy.
