Meta analysis on MCP-1-2518G/A gene polymorphism and susceptibility of diabetic nephropathy
10.3969/j.issn.1671-8348.2017.36.032
- VernacularTitle:单核细胞趋化蛋白-1-2518G/A位点基因多态性与糖尿病肾病易感性的Meta分析
- Author:
Xiongyan ZHANG
1
;
Yixin HUANG
;
Peng CHENG
Author Information
1. 浙江省台州市肿瘤医院内分泌科 317500
- Keywords:
monocyte chemotaxis protein-1;
MCP-1-2518G/A;
gene;
polymorphism;
genetic;
diabetic nephropathy;
Meta a-nalysis
- From:
Chongqing Medicine
2017;46(36):5137-5140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relation between MCP-1-2518G/A gene polymorphism and the onset risk of diabetic nephropathy(DN) by the data of collected and publishedcase control studies and using the meta analysis method .Methods All lit-eratures on moncyte chemoattractant protein-1(MCP-1)-2518G/A gene polymorphism and the onset risk of DN included in the da-tabases of PubMed ,Web of Science ,EMbase ,Cochrane Library ,CNKI ,Wanfang and VIP until October 2016 were systametically re-trieved .Then the related data were extracted .The Stata11 .0 statistical software was used to calculate the odds ratio (OR) of syn-thetic data and 95% confidence interval (CI) ,meanwhile the heterogeneity and publication bias of the studies were evaluated .Re-sults A total of 9 studies were included involving 2767 independent samples ,the number of cases was 1096 ,the control number was 1671 .For the general population ,the relationship between MCP-1 gene-2518G/A polymorphism and the onset risk of DN was not found in 4 gene models (dominant model:OR=1 .01 ,95% CI:0 .67-1 .54 ;recessive model :OR=0 .93 ,95% CI:0 .60-1 .44 ;homo-zygous model:OR=0 .93 ,95% CI:0 .70 -1 .23 ;heterozygous model :OR=0 .89 ,95% CI:0 .61-1 .31) .The subgroup analysis re-sults showed that in India population ,MCP-1-2518G/A gene polymorphism might significantly increase the onset risk of DN (domi-nant model:OR=1 .56 ,95% CI:1 .19 -2 .06) ,but in Chinese ,Turks or South Koreans ,the MCP-1-2518G/A gene polymorphism had no relation with the onset risk of DN .Conclusion In the general population ,MCP-1-2518G/A gene polymorphism has no rela-tion with the onset risk of DN .But the MCP-1 gene-2518G/A polymorphism can increase the onset risk of DN in India population , while does not increase the onset risk of DN in Chinese population ,Korean population and Turkey population .
