Treatment Strategies for Carbapenem-resistant Enterobacteriaceae Infections
10.3870/j.issn.1004-0781.2018.01.001
- VernacularTitle:耐碳青霉烯类肠杆菌科细菌感染治疗策略研究进展
- Author:
Tingting XIAO
1
;
Yonghong XIAO
Author Information
1. 浙江大学医学院附属第一医院传染病诊治国家重点实验室、感染性疾病诊治协同创新中心
- Keywords:
Carbapenem;
Resistant;
Enterobacteriaceae;
Infection;
Treatment strategies
- From:
Herald of Medicine
2018;37(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective Carbapenem-resistant Enterobacteriaceae infections is becoming a major challenge to clinicians, which resulted in extremely high mortality owing to the limited antibiotics option.It is urgently to explore strategies to manage such bacterial infections.So far,the research is mainly focused on the research and development of new drugs,as well as the re-evaluation of classic antimicrobial drugs and the combined treatment regimens.Tigecycline is available in our country,but the clinical effect is still doubtful.Polymyxin has a good effect on drug sensitivity test in vitro,but the clinical dosing has not been established.Carbapenems combining with other drugs as optimizing treatment program is also being explored.Carbapenemase-inhibitor combination has not yet listed on Chinese market.In the mean time,it is urgent to prevent and to control carbapenem-resistant Enterobacteriaceae bacterial infection.
