Predictive Value of Plasma Fibrin Monomer Level on Postoperative Venous Thromboembolism in Fracture of Lower Limb
10.3969/j.issn.1671-7414.2017.05.036
- VernacularTitle:血浆纤维蛋白单体水平检测对下肢骨折术后静脉栓塞的预测价值
- Author:
Hu LI
1
Author Information
1. 上海市宝山区罗店医院检验科
- Keywords:
fibrin monomer;
venous thromboembolism;
fracture;
D-dimer
- From:
Journal of Modern Laboratory Medicine
2017;32(5):133-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of plasma fibrin monomer (FM) level on postoperative venous thromboembolism (VTE) in fracture of lower limb.Methods Retrospectively analyzed the clinical data of 126 patients underwent internal fixation of lower limb fracture from January to December 2016,including perioperative plasma prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (Fib),D-dimer (DD) and FM.And all patients were divided into VTE group (n=19) and non-VTE group (n=107) according to the venous color Doppler ultrasonography of lower limb and follow up result.The change of coagulation and fibrinolysis indexes were compared before and after operation,and the area under the receiver operating characteristic curve (AUC) was performed to evaluate these indicators' predictive value for postoperative VTE.Results ①APTT,Fib,DD and FM increased significantly after operation in all patients (F=3.550 ～ 9.223,all P＜ 0.05).Among them,FM increased significantly at 1 d after operation,then gradually decreased.②There were no significant differences in APTT,Fib,DD and FM before operation between two groups (F=0.652～1.120,all P＞0.05).Compared with non-VTE group,FM at 1,3 and 5d after operation increased significantly (t=2.548～ 2.883,all P＜0.05),in which the difference of each index were largest at 3d after operation.③In four indexes including APTT,Fib,DD and FM at 3d after operation,the AUC and Youden index of FM were largest [0.713 (95％ CI.0.620 ～ 0.823) and 0.399].Conclusion There were coagulation and fibrinolysis system activated in fracture of lower limb after operation.Plasma FM at 3d after operation had high predictive value of postoperative VTE,and its effect was better than DD.
