Correlation between oral Helicobacter pylori infection and oral lichen planus:a systematic review
10.3969/j.issn.1673-4130.2017.24.003
- VernacularTitle:口腔幽门螺杆菌感染与口腔扁平苔藓相关性的系统评价
- Author:
Yangyang SHE
1
;
Yizhou LIANG
;
Xiaoling NONG
Author Information
1. 广西医科大学口腔医学院口腔医院口腔颌面外科
- Keywords:
Helicobacter pylori;
oral lichen planus;
systematic review;
case-control study
- From:
International Journal of Laboratory Medicine
2017;38(24):3365-3367,3370
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was performed to explore the association between oral Helicobacter pylori(HP)infection and oral lichen planus(OLP).Methods Some online electronic databases such as PubMed,Embase,Cochrane Library,CNKI,Wanfang and Chongqing VIP were searched for the eligible case control studies.The association between oral HP infection and OLP was esti-mated by the pooled odds ratios(OR)and 95% confidence intervals(95% CI).Statistical analyses were performed by using STA-TA11.0 software.Fixed or random effects model was used to calculate ORs and 95% CI according to heterogeneity.Results A total of 7 studies with 307 patients and 207 healthy controls were included in the current study.The results of meta-analysis showed the patients with OLP had a significantly higher prevalence of oral HP infection compared with the healthy population(OR=8.43, 95% CI:2.90-24.52,P<0.001).Conclusion This study suggested that HP may be a risk factor for OLP.These findings may guide new strategies for OLP therapy and prevention.However,due to the influence of the quality of the included literature,addi-tional high quality of studies with larger sample sizes are needed.
