Research progress of RCAN1 in malignant tumor
10.11904/j.issn.1002-3070.2017.06.015
- VernacularTitle:RCAN1在恶性肿瘤中的研究进展
- Author:
Ying JIANG
1
Author Information
1. 哈尔滨医科大学附属肿瘤医院 哈尔滨 150081
- Keywords:
RCAN1;
Tumors;
Progression
- From:
Practical Oncology Journal
2017;31(6):559-563
- CountryChina
- Language:Chinese
-
Abstract:
Regulation of calcineurin 1(RCAN1),as an endogenous protein that interacts with calcineurin ( CaN) ,widely expresses in many malignant tumor cells,such as small cell lung cancer,thyroid cancer,leukemia, liver cancer,malignant glioma,endometrial adenocarcinoma and so on. In recent years,many studies have been shown that when RCAN1 is highly expressed,it can inhibit tumor proliferation,differentiation,invasion and metas-tasis by a variety of ways,thereby inhibiting tumor progression. These findings play an important role in the surviv-al and prognosis of patients,and provide a theoretical basis for the treatment and intervention of malignant tumors.
