Effect of Different Dosage forms of Gonadotrophin-Releasing Hormone Agonist on In-Vitro Fertilization-Embryo Transfer in Patients with Mild Endometriosis
- VernacularTitle:不同方案GnRH-a降调节对轻中度子宫内膜异位症患者体外受精-胚胎移植结局的影响
- Author:
Fang WANG
1
;
Xue KE
;
Min LI
Author Information
1. 成都市妇女儿童中心医院
- Keywords:
Gonadotropin-releasing hormone agonist;
Endometriosis;
Pro-long protocols;
Long protocols;
Short-acting protocols
- From:
Journal of Practical Obstetrics and Gynecology
2017;33(11):869-872
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of different dosage forms of gonadotropin-releasing hormone agonist(GnRH-a) on in vitro fertilization-embryo transfer(IVF-ET) in patients with mild endometriosis.Methods:Totally 269 cycles(175 cases) of IVF-ET were included,which was divided into three groups:pro-long protocols (long acting 3.75 mg group,102 cycles),long protocols (long acting 1.875 mg group,87 cycles) and short protocols(short-acting 0.1 mg group,80 cycles).The clinical results were compared among groups.Results:The amount of gonadotropin(Gn) were significantly higher in pro-long protocol than the other ones.The implantation rate and clinical pregnancy rate were significantly higher in long acting 1.875mg group than the other two protocols (P ＜ 0.05).Conclusions:Long protocol (long acting GnRH-a down-regulation,1o 875 mg) may be more beneficial to improve the implantation rate and clinical pregnancy rate of in vitro fertilization-embryo transfer(IVF-ET) in patients with endometriosis.
