Experimental Study on Acute Toxicity of Momordica Cochinchinensis in Mice
- VernacularTitle:木鳖子提取物对小鼠急性毒性实验研究
- Author:
Lei ZHENG
1
;
Ruofei YANG
;
Fu YANG
;
Miaoyu LI
Author Information
1. 西安医学院药学院 西安710021
- Keywords:
Momordica Cochinchinensis;
Mice;
Acute toxicity
- From:
China Pharmacist
2017;20(12):2242-2243,2290
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the acute toxicity of Momordica Cochinchinensis in mice, observe and evaluate the acute toxicity of Momordica Cochinchinensis herbs in order to provide basis for the safe and reasonable clinical medication. Methods: According to the classic experiment methods, the acute toxicity of Momordica Cochinchinensis in mice was compared with different administration meth-ods, and the LD50 was calculated by the Bliss method with the continuous administration and observation for 7 d. At the end of the tri-al, the pathologic changes of the relevant organs were also observed. Results:The LD50 of Momordica Cochinchinensis in mice with oral administration was 4. 03g·kg-1 , and the 95% confidence interval was 3. 29-4. 92 g·kg-1 . The LD50 of Momordica Cochinchinensis in mice with intraperitoneal injection was 146. 17 mg·kg-1 , and the 95% confidence interval was 118. 92-177. 31 mg·kg-1 . Conclu-sion:The Momordica Cochinchinensis extract is poisonous, which is consistent with the literatures and pharmacopoeia. By comparing the acute toxicity with different administration methods of Momordica Cochinchinensis in mice, it is beneficial to the evaluation of acute toxicity of Momordica Cochinchinensis to provide basis for the reasonable medication in clinics.
