Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients
10.3969/j.issn.1671-7414.2017.06.020
- VernacularTitle:骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析
- Author:
yan Yuan TANG
1
;
ming Li ZHANG
;
zhao Jiang ZHANG
;
Tao XIONG
;
Yan LIANG
;
jun Zhuo YU
;
min Hui LIU
;
Min LIU
;
ping Zhi HUANG
Author Information
1. 华中科技大学同济医学院附属荆州医院血液内科
- Keywords:
myelodysplastic syndrome;
dysplasia;
fluorescence in situ hybridization
- From:
Journal of Modern Laboratory Medicine
2017;32(6):71-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between morphological abnormalities and abnormal myelodysplastic syn-dromes(MDS)cloning.Methods 82 cases of MDS were collected with complete FISH and morphological abnormalities. The relationship between MDS cell morphology and chromosome abnormality was investigated.Results 45 cases of chromo-somal abnormalities were found,and +8 were the most frequent chromosomal abnormalities.8 cases were +8,-5 and 5q-were 6,20q-were 7,-7 and 7q-were 5,complex karyotypes(>3 abnormalities)were 6.There were statistically significant differences in the proportion of primordial cells,megakaryocyte dysplasia,megakaryocyte abnormalities between karyotype abnormal group and karyotype normal group(P<0.05).There were statistically significant differences in the proportion of abnormal karyotype among high risk group and low risk group,the low risk group and medium risk group(P<0.05).Con-clusion The chromosomal abnormalities of MDS patients would be related to morphological changes.
