Study on the Relationship between Peptides and Interleukin-17A, Tumor Necrosis Factor α in Children Kawasaki Coronary Artery Disease
10.3969/j.issn.1671-7414.2017.06.014
- VernacularTitle:儿童川崎病患者血浆和肽素,IL-17A,TNF-α检测与冠脉病变的相关性研究
- Author:
hua Xiao YAN
1
;
min Tao BAI
;
Juan MA
;
Wang HE
;
Na GAO
;
Nan ZHOU
Author Information
1. 陕西省人民医院 西安交通大学医学院第三附属医院
- Keywords:
children kawasaki disease;
peptides;
IL-17;
TNF-α;
coronary artery disease
- From:
Journal of Modern Laboratory Medicine
2017;32(6):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of Peptides and Interleukin-17A,Tumor necrosis factorαin children kawasaki coronary artery disease.Methods 60 patients,made a definite diagnosis as kawasaki coronary artery disease(32 cases of male,28 cases of female,average age 2.5 years),40 healthy subject were enrolled in the study(23 cases of male,fe-male 17 cases,with an average age of 3 years of age).The plasma levels of Peptides,Interleukinin 17A(IL-17A)and Tumor necrosis factorα(TNF-α)in each group was detected by ELISA.Results ①The plasma levels of Peptides,Interleukinin 17A (IL-17A)and Tumor necrosis factorα(TNF-α)was significantly higher than healthy controls,respectively(21.09±2.72) vs(18.45±2.96)pmol/L,t=6.13,P<0.01,(21.20±2.35)vs(18.80±2.20)pg/ml,t=8.586,P<0.01;(50.84±5.81) vs(45.24±6.15)pg/ml,t=7.278,P<0.01.②Results of ROC curves showed,the sensitivity of Peptides in kawasaki coro-nary artery disease was 88.2%,the specificity was 75.0% and the sensitivity of IL-17A was 85.3%,the specificity was 79.2%,the sensitivity of TNF-αwas 88.2%,the specificity was 73.6%.Conclusion The plasma levels of Peptides,IL-17A and TNF-αin acute phase of kawasaki coronary artery disease were all increased.Combined detections of peptide,IL-17A and TNF-αmay predict the incidence of coronary artery disease in children with kawasaki disease.
