Association between Polymorphism of Endothelin Receptor Type A and Delayed Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage
10.3969/j.issn.1671-7414.2017.06.016
- VernacularTitle:EDNRA基因rs5335多态性与aSAH后迟发性脑血管痉挛的关联性研究
- Author:
Feng ZHU
1
;
Peng ZHANG
;
rong Jian SONG
;
Bei HE
;
Yuan LIANG
Author Information
1. 宝鸡市中心医院神经外科
- Keywords:
endothelin receptor type A;
aneurysmal subarachnoid hemorrhage;
delayed cerebral vasospasm;
gene polymorphism
- From:
Journal of Modern Laboratory Medicine
2017;32(6):56-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic association between endothelin receptor type A(EDNRA)gene polymor-phism and delayed cerebral vasospasm(DCVS)in patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods 133 aSAH patients from January 2015 to January 2017 were recruited to participate in the study.According to whether com-bined with DCVS,they were divided into the DCVS group(78 cases)and the control group(55 cases).Genotype was deter-mined by polymerase chain reaction-restriction fragment length polymorphism combined with DNA direct sequencing tech-nique for the polymorphism of the EDNRA gene.Results Samples of DCVS group and control group both were consistent with Hardy-Weinberg's law of inheritance(χ2=0.295,P=0.863;χ2=0.652,P=0.722).There were significant differ-ences of EDNRA gene rs5335 polymorphism between DCVS group and control group,under allele model(χ2=4.213,P=0.040)and the dominant model(χ2=4.790,P=0.029).However,there was no difference of EDNRA gene polymorphism between DCVS group and control group under recessive model(χ2=1.299,P=0.254).Multivariate Logistic regression a-nalysis showed that allele C was protective factor of DCVS for aSAH patients(OR=0.572,95%CI 0.401~0.872,P=0.021).Conclusion For aSAH patients,EDNRA gene rs5335 polymorphism may closely related to DCVS.
