Research advances in primary biliary cholangitis complicated by osteoporosis

VernacularTitle:原发性胆汁性胆管炎并发骨质疏松的研究现状
Author: Jian ZHAO ¹ ; Hao TIAN ; Dingkang YAO
Author Information

1. 第二军医大学长征医院内科学教研室
Keywords: cholangitis; osteoporosis; review
From: Journal of Clinical Hepatology 2017;33(11):2226-2229
CountryChina
Language:Chinese
Abstract: Osteoporosis is a common complication of primary biliary cholangitis (PBC) with a relatively high prevalence rate and a high risk of bone fracture.The pathogenesis of osteoporosis remains unknown.This article reviews the latest advances in the pathogenesis and treatment of osteoporosis in PBC.Studies have shown that osteoporosis in PBC has various causes,including increased bone absorption and reduced bone formation due to many factors.Although many drugs have been used in clinical practice,until now,bisphosphonates are still the most effective drugs.Long-term systematic studies are needed in the future to clarify their effects on fracture in PBC patients.