Prognostic value of 18F-FDG PET-CT in patients with diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2017.09.003
- VernacularTitle:18F-FDG PET-CT在弥漫大B细胞淋巴瘤预后判断中的价值
- Author:
Bin HUANG
1
;
Tiannyu LI
;
Chongyang DING
Author Information
1. 210008,南京大学医学院附属鼓楼医院肿瘤科
- Keywords:
Lymphoma;
large B-cell;
diffuse;
Prognosis;
Tomography;
X-ray computed;
Fluorodeoxyglucose F18
- From:
Journal of Leukemia & Lymphoma
2017;26(9):523-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of 18F-FDG PET-CT in patients with diffuse large B-cell lymphoma(DLBCL).Methods The clinical data of 130 DLBCL patients from June 2009 to May 2015 and pretreatment 18F-FDG PET-CT were retrospectively analyzed.Results The 130 DLBCL patients' median of maximal standard uptake value(SUVmax),metabolic tumor volume(MTV)and total lesion glycolysis(TLG)was 19.93,34.45 cm3,459.92 respectively.Univariate analysis showed that the affecting factors of progression-free survival(PFS)and overall survival(OS)rate included Eastern Cooperative Oncology Group(ECOG)grade,Ann Arbor stage,β2-MG,lactate dehydrogenase level,tumor diameter,bone marrow involvement,National Comprehensive Cancer Network International Prognostic Index(NCCN-IPI),MTV and TLG(all P <0.05),while age was related with PFS rate(P<0.05).As MTV and TLG were strongly correlated,only TLG measure was used for multivariate analysis.The result showed that ECOG grade,Ann Arbor stage,NCCN-IPI and TLG were statistically significant predictors of PFS rate,and NCCN-IPI and TLG were independent factors of OS rate(all P<0.05).According to TLG and NCCN-IPI,the patients were divided into three groups: low risk group,mediate risk group and high risk group.The 3-year PFS rates of these groups were 66.0%,36.8% and 26.1% respectively(P< 0.05),and the 3-year OS rates of these groups were 70.0%,49.1% and 39.1% respectively(P < 0.05).Conclusion TLG in 18F-FDG PET-CT is an independent prognostic factor for PFS and OS in patients with DLBCL,which has a reference value for prognosis of DLBCL.
