Progress in Application of Peripheral Blood Methylated SEPT9 Gene Assay for Colorectal Cancer Screening
10.3969/j.issn.1008-7125.2017.10.009
- VernacularTitle:外周血SEPT9基因甲基化检测在结直肠癌筛查中的应用进展
- Author:
Xia LENG
1
;
Weichang CHEN
Author Information
1. 苏州大学附属第一医院消化内科 215006
- Keywords:
Colorectal Neoplasms;
Screening;
Early Diagnosis;
DNA Methylation;
SEPT9 Gene
- From:
Chinese Journal of Gastroenterology
2017;22(10):619-622
- CountryChina
- Language:Chinese
-
Abstract:
The early detection and diagnosis of colorectal cancer (CRC)is of great clinical importance. Peripheral blood methylated SEPT9 gene was found to be a sensitive and specific biomarker for CRC and was superior to other commonly used screening methods such as fecal occult blood test,serum tumor markers and colonoscopy in a variety of studies. But it is of limited value in screening of adenomas,polyps and other precursors of CRC,and its capacities for assessment of cancer recurrence and therapeutic effects of radiotherapy and chemotherapy need further clinical validation. This article reviewed the progress in application of peripheral blood methylated SEPT9 gene assay for CRC screening.
