Efficacy of Yinxing-Tongzhi dripping pills combined with clopidogrel in the secondary prevention of non cardiac cerebral infarction
10.3760/cma.j.issn.1673-4246.2017.10.005
- VernacularTitle:银杏酮酯滴丸联合氯吡格雷在非心源性脑梗死二级预防中的疗效分析
- Author:
Xiao LI
1
;
Yinhua ZHANG
Author Information
1. 215600,江苏省张家港市第六人民医院心内科
- Keywords:
Brain infarction;
Secondary prevention;
Clopidogrel;
Yinxing-Tongzhi dripping pills;
Recurrence
- From:
International Journal of Traditional Chinese Medicine
2017;39(10):883-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy ofYinxing-Tongzhi dripping pills combined with clopidogrel in the secondary prevention of non cardiac acute cerebral infarction (ACI).Methods A total of 117 patients met the inclusion criteria in our hospital were divided into the control group (58 cases) and observation group (59 cases). The control group was orally clopidogrel 75 mg/d in prevention of ACI recurrence, and the observation group addedYinxing-Tongzhi dripping pills based on the treatment of control group, each time 50 mg tid. Both groups were fellowed-up 1 year. The color Doppler ultrasound was used for determination of carotid artery interior and medial thickness (IMT), maximum thickness of the common carotid artery, internal carotid artery, external carotid artery plaques for evaluation. The carotid plaque score was introduced into evaluation of crouse plaque; blood rheometer was used for testing of whole blood viscosity (BV) and plasma viscosity (PV); automatic biochemical analyzer was used for testinghigh sensitive protein (hs-CRP), D-dimer and homocysteine (HCY). The patient's infertility response was recorded during the medication,and adverse drug reactions of the two groups were compared.Results The reductions on IMT (0.18 ± 0.07vs. 0.12 ± 0.04,t=5.679)mm and carotid plaque score (1.25 ± 0.31vs. 1.04 ± 0.26,t=5.009) of the observation group after follow-up were significantly higher than the control group (P<0.05). The reductions on low shear BV (0.73 ± 0.19vs. 0.51 ± 0.16,t=6.769) mPa?s and PV (0.37 ± 0.09vs. 0.22 ± 0.05,t=11.117) mPa?s of the observation group after follow-up were significantly higher than the control group (P<0.05). The reductons on hs-CRP (3.67 ± 0.88vs. 2.65 ± 0.75,t=6.742) mg/L, D-dimer (107.6 ± 23.8vs. 89.3 ± 18.7,t=4.629) g/L、Hcy (15.1 ± 2.9vs. 11.7 ± 2.6,t=6.679) mol/L of the observation group were significantly higher than the control group (P<0.05). The observation group with incidences of transient ischemic attack (8.5%vs. 19.0%), ACI recurrence (0vs. 8.6%), cerebrovascular death (0vs. 1.7%) were significantly lowerer than the control group. The ACI recurrences of the two groups with statistically significant difference (P=0.027).Conclusions Based on orally clopidogrel in secondary prevention of ACI,Yinxing-Tongzhi dripping pills combined can reduce blood viscosity, inhibit atherosclerotic plaque growth, reduce ACI recurrence, and with no increase of adverse reactions.
