Raman Spectroscopy Analysis and Dissolution Experiment of Nimodipine in Two Crystal Forms
10.3870/j.issn.1004-0781.2017.10.021
- VernacularTitle:尼莫地平两种晶型的拉曼光谱分析和溶出度实验
- Author:
Lingtai JIAO
1
;
Li ZHANG
;
Dezhi YANG
;
Shiying YANG
;
Guanhua DU
;
Yang LYU
Author Information
1. 北京协和医学院&中国医学科学院药物研究所晶型药物研究北京市重点实验室
- Keywords:
Nimodipine;
Crystal forms;
X-ray diffraction,powder;
Analysis,Raman spectroscopy;
Dissolution
- From:
Herald of Medicine
2017;36(10):1175-1179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish an innovative methods for the identification of nimodipine polymorphs. Methods Nimodipine of two crystal forms were prepared by rapid solvent removal and identified by powder X-ray diffraction, infrared spectroscopy and Raman spectroscopy.The dissolution study of the powder samples were carried out in six different mediums. Results Powder X-ray diffraction patterns of crystal form A and B could be used for the identification of crystal forms of nimodipine.Crystal form B has characteristic diffraction peaks at 2θ=5° and 2θ=13° in the pattern,while crystal form A has characteristic diffraction peaks at 2θ=27° distinguishing two crystal forms effectively. Raman spectrum could be used to identify the crystal forms.Compared with Raman spectra of crystal form B, there exists characteristic scattering peak at 500 cm-1 in crystal form A. According to the position and intensity of the peaks of crystal form A and B, it could distinguish two crystal types effectively.The results of dissolution tests showed that the solubility of crystal form A is better than crystal form B. Conclusion Various analysis techniques in different principle were used in the research, such as Powder X-ray diffraction, Infrared spectroscopy and Raman Spectroscopy etc.Crystal forms were confirmed in several aspects according to the properties of different crystal form, and the solubility of crystal form A is better than crystal form B.
