The early diagnostic value of Let-7b for esophageal cancer
10.3969/j.issn.1673-4130.2017.20.001
- VernacularTitle:循环标志物let-7b对食道癌的早期诊断意义研究
- Author:
Pengcheng LI
1
;
Bin WU
;
Guanxin SHEN
;
Li DENG
;
Juan LIU
;
Shun WANG
Author Information
1. 华中科技大学同济医学院附属中西医结合医院/武汉市第一医院输血科
- Keywords:
esophageal cancer;
biomarkers;
let-7b
- From:
International Journal of Laboratory Medicine
2017;38(20):2801-2803,2807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate diagnostic value of miRNAs for esophageal cancer .Methods Blood samples were obtained from patients with esophageal cancer .MiRNAs including miR-30a ,miR-126a ,let-7b were detected and compared with healthy con-trols .After adjusting smoking and insobriety ,Logistic regression was used to judging which was best for clinical guidance .ROC curve was used to analyzed the clinic value of these miRNAs .Results Age of the two groups had no significant difference(P>0 .05) .The levels of smoking ,alcoholism and family history of cancer in the two groups had significant difference (P<0 .05) .Two groups′miR-30a levels in plasma had no significant differences (P>0 .05) .Let-7b and miR-126a levels in plasma in patients with e-sophageal were significantly higher in healthy volunteers (P<0 .05) .After adjustment the factors of smoking and alcohol ,let-7b lev-els were associated with the risk of esophageal cancer (P<0 .05) .Area under the ROC curve was 0 .712 ,which had a certain esoph-ageal cancer diagnostic performance .Conclusion Plasma let-7b could be treated as a biomarker for the diagnosis of esophageal canc-er.
