Research progress of LncRNA and chemotherapy resistance in gastrointestinal neoplasms
10.11904/j.issn.1002-3070.2017.05.012
- VernacularTitle:LncRNA与胃肠道肿瘤化疗耐药的研究进展
- Author:
Lina SUN
1
;
Xiaodi ZHAO
Author Information
1. 肿瘤生物学国家重点实验室、第四军医大学西京消化病医院
- Keywords:
LncRNA;
Gastrointestinal neoplasms;
Gastric cancer;
Colorectal cancer;
Chemodrug resist-ance
- From:
Practical Oncology Journal
2017;31(5):448-453
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal tumor chemotherapy resistance makes many patients be fail treatment,and its mechanism is unclear.The long-chain non-coding RNA(LncRNA)was found in the transcription,transcription and epigenetic,and other aspects of the regulation of the pathophysiology of the body.Many studies have found that LncRNA is also closely related to gastrointestinal cancer resistance drugs.LncRNA is not only closely related to the ten characteristics of the tumor,but it also regulates gastrointestinal cancer resistance by the impact of drug transporter,competitive endogenous RNA in the way of action,affecting tumor cell apoptosis,and regulating epi-thelial mesenchymal transition process.This article will review gastrointestinal cancer-related LncRNA and its participation in gastrointestinal resistance mechanism.
