Current status of the establishment of acute promyelocytic leukemia in mouse models
10.11904/j.issn.1002-3070.2017.05.013
- VernacularTitle:急性早幼粒细胞白血病小鼠动物模型建立的研究现状
- Author:
Yitong WANG
1
Author Information
1. 哈尔滨医科大学免疫教研室
- Keywords:
Acute promyelocytic leukemia;
Animal model;
FVB/NJ mice
- From:
Practical Oncology Journal
2017;31(5):454-457
- CountryChina
- Language:Chinese
-
Abstract:
Acute promyelocytic leukemia(APL)is a class of malignant disease of hematopoietic tissue. Animal models are important tools for exploring human-related diseases.Many studies have beer shown that APL mouse models can be established by transgenic,retroviral-mediated and leukemia cell transplantation.These models established by these three methods can be re-transplanted.The establishment of these models lays the foundation for understanding the pathogenesis and efficacy of APL.In order to determine whether the model is successfully established,these methods can be used for blood tests,blood smear and bone marrow smear,immunol-ogy,molecular biology and pathology related to complete the examination.Successful establishment of APL animal model can provide important experimental basis and theoretical basis for the study,development and evaluation of drug efficacy in APL,which will help people to understand human APL further.
