Influence of tanshinone injection combined diltiazem on vascular endothelial function in patients with hypertension
10.3969/j.issn.1008-0074.2017.05.08
- VernacularTitle:丹参酮注射液并地尔硫卓对高血压患者血管内皮 功能的影响
- Author:
Hong JIA
1
;
Qin LIU
Author Information
1. 中国民用航空飞行学院飞机修理厂
- Keywords:
Hypertension;
Endothelium;
vascular;
Tanshinone;
Diltiazem
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(5):490-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influence of tanshinone injection combined diltiazem on vascular endothelial function in patients with hypertension.Methods:A total of 136 inpatients with essential hypertension were selected from our hospital. According to random number table,they were randomly and equally divided into diltiazem group and combined treatment group (received tanshinone injection combined diltiazem).Blood pressure,endothelium dependent dilation (EDD)were compared between two groups before,two weeks and one month after treatment.Results:Compared with before treatment [combined treatmant group: (168.25 ± 12.54)/ (112.47 ±6.28)mmHg;diltiazem group: (168.37 ± 1174.16)/(112.49±7.13)mmHg],there was significant reduction in blood pressure in two groups on two weeks and one month af-ter treatment;compared with diltiazem group on two weeks and one month after treatment,there was significant reduction in blood pressure [two weeks:(151.36±6.16)/ (109.17±4.76)mmHg vs.(142.37±2.43)/ (100.43±5.19)mm-Hg,one month:(142.34±6.28)/ (94.16±6.28)mmHg vs.(126.71 ±8.17)/ (87.49±5.37)mmHg]in combined treatment group,P <0.01 all.Compared with before treatment [Combined treatmant group:(4.78±2.30)%;diltiazem group:(4.74±2.28)%],there was significant rise in EDD in two groups on two weeks and one month after treatment;compared with diltiazem group on one month after treatment,there was significant rise in EDD [(6.69 ±4.60)% vs. (8.43±4.73)%]in combined treatment group,P <0.05 or <0.01. Conclusion:Diltiazem combined tanshinone injection can help to improve vascular endothelial function in patients with hypertension.
