Research progress of senescence-associated secretory phenotype and vascular aging
10.3760/cma.j.issn.0254-9026.2017.10.022
- VernacularTitle:衰老相关分泌表型与血管衰老的研究进展
- Author:
Xue WANG
1
;
Jing YANG
;
Yan LEI
Author Information
1. 中国中医科学院医学实验中心
- Keywords:
Aging;
Blood vessels
- From:
Chinese Journal of Geriatrics
2017;36(10):1151-1155
- CountryChina
- Language:Chinese
-
Abstract:
Vascular senescence is associated with aging and disease in various organ and systems of the human body,and is one of the main pathogenesis of chronic diseases such as heart,brain,kidney and others.Vascular cell senescence expresses a senescence-associated secretory phenotype (SASP),including proinflammatory cytokines,growth factors,chemokines and proteases.These factors accelerate the changes in vascular structure and function,and lead to vascular aging.This study focuses on the latestresearchprogressions of the mechanism,biological effects of SASP,relationship between SASP and vascular aging,and intervention on SASP.
