Angiocentric Immunoproliferative Lesions of the Nasal Cavity.
- Author:
Mi Kyung YE
1
;
Chul Hee LEE
;
June Sik PARK
Author Information
1. Department of Otolaryngology, College of Medicine, Catholic University of Taegu-Hyosung, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Angiocentric immunoproliferative lesion;
Non-Hodgkin's lymphoma;
T-cell Epstein-Barr virus
- MeSH:
Gyeongsangbuk-do;
Herpesvirus 4, Human;
Humans;
In Situ Hybridization;
Lymphoma, Non-Hodgkin;
Nasal Cavity*;
Necrosis;
Otolaryngology;
Survival Rate;
T-Lymphocytes
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(5):501-506
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: In the past years angiocentric immunoproliferative lesion was described as various terms and histologically characterized by polymorphism, angiodestruction, and necrosis. This study was carried out to analyze the clinical profile, the results of treatment, and immunohistochemical nature of the angiocentric immunoproliferative lesion of the nasal cavity. In addition, we aimed to estimate the significance of Epstein-Barr virus infection as a causative agent in this disease. MATERIAL AND METHODS: We performed clinical and pathologic review of patients with the destructive sinonasal lesions, who were treated at the department of Otolaryngology, Kyungpook National University. Immunohistochemical staining was done in 28 cases and EBER in situ hybridization was done in 14 cases. RESULTS: The overall five-year survival rate was 62%. Immunohistochemical study showed positive reaction to the T-cell surface marker and Epstein-Barr virus was detected in all tested cases. CONCLUSION: Nasal cavity AIL was non-Hodgkin's lymphoma, and of T-cell origin, and was closely related with the Epstein- Barr virus infection. It may be worthwhile to evaluate its pathogenesis in relation with Epstein-Barr virus infection and study the appropriate treatment method.
