Distribution of Beta-Catenin Expression in Adenoid Cystic Carcinoma of the Head and Neck.
- Author:
Choong Sik CHOI
1
;
Geon CHOI
;
Jae Joon SONG
;
Kyu Sung HWANG
;
Kwang Yoon JUNG
;
Jong Ouck CHOI
Author Information
1. Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
beta-catenin;
Adenoid cystic carcinoma;
Immunohistochemistry
- MeSH:
Actin Cytoskeleton;
Adenoids*;
Antibodies, Monoclonal;
beta Catenin*;
Carcinoma, Adenoid Cystic*;
Classification;
Cytoplasm;
Head*;
Humans;
Immunohistochemistry;
Neck*;
Signal Transduction
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2000;43(2):188-192
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: beta-catenin has functions in cell-cell adhesion with a complex of proteins that link cadherin to the cortical actin cytoskeleton and signal transduction through wnt developmental pathway. In this study, we investigated the distribution of beta-catenin in adenoid cystic carcinoma according to the histologic subtypes, perineural invasion, T classification, nodal status and stage. MATERIALS AND METHODS: Each formalin-fixed paraffin-embedded surgical specimens were obtained from seventeen patients with adenoid cystic carcinoma. We performed immunohistochemical staining with beta-catenin monoclonal antibodies and compared its staining patterns with patients' clinical characteristics. RESULTS: In tubular subtype, there were intense membranous staining pattern than other subtypes (p<0.05). Cytoplasmic and nucleus staining were more observed in cribriform subtype (p<0.05), but weak in solid subtype (p<0.05). There were no correlation between beta-catenin staining patterns and other clinical characteristics (p>0.05). CONCLUSIONS: It is suggest that there are mixed functional roles of beta-catenin in adenoid cystic carcinoma in tumor aggressiveness.
