A Immunohistochemical Study of Expression of Inducible Isoform of Heme Oxygenase on Human Nasal Polyps.
- Author:
Su Yeob PARK
1
;
Tae Wook CHOI
;
Jung Hun LEE
;
Sang Heon CHOI
;
Jae Hoon LEE
;
Ki Jung YUN
Author Information
1. Department of Otolaryngology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea. coolnose@wonnms.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Nasal polyp;
HO-1;
Oxidative stress
- MeSH:
Adrenal Cortex Hormones;
Heme Oxygenase (Decyclizing)*;
Heme*;
Humans*;
Macrophages;
Mucous Membrane;
Nasal Mucosa;
Nasal Polyps*;
Oxidative Stress;
Turbinates
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2005;48(5):619-623
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Nasal polyp is non-neoplastic, chronic inflammatory disease of the nasal mucosa. Oxidative stress may be related to the pathogenesis of nasal polyp. Oxidative stress may be potential inducers of heme oxygenase (HO-1) expression. To illustrate the role of the HO-1 in the nasal polyp, we investigated the expressive pattern of the HO-1 in the nasal polyp and the influence of corticosteroids on its expression. SUBJECTS AND METHOD: The study materials were 28 specimens of nasal polyp (steroid user: 13 cases, steroid non-user: 15 cases) taken from 28 patients during endoscopic sinus surgery and 11 cases of normal nasal mucosa of the inferior turbinate as control. The HO-1 expression was assessed by immunohistochemical staining. RESULTS: The HO-1 was mainly expressed on non-epithelial cells in the lamina propria of nasal polyps in 20/28 (71.4%). The expression of HO-1 was positive in 11 out of 13 (84.6%) and 9 out of 15 (60%) subjects for steroid user and steroid non-user group, respectively. The inflammatory cells were almost identified as macrophage by using a macrophage specific marker (CD68+). The HO-1 was not expressed in normal control at all. There was no significant difference in the expression of HO-1 between the steroid user group and the non-user group. CONCLUSION: HO-1, as an important endogenous antioxidant enzyme, may play a protective role in the pathogenesis of nasal polyp. Steroid may not regulate the HO-1 expression in the nasal polyp.
