The effect of medicinal herb administration to arthritis inducded rabbit arthritistreatment.
10.4163/kjn.2012.45.5.437
- Author:
Tae Dong KWON
1
;
Ki Hoon KIM
Author Information
1. Department of Leisure Sport, Kyungpook National University, Sangju 742-711, Korea. tdkwon6086@hanmail.net
- Publication Type:Original Article
- Keywords:
medicinal herbs;
arthritis;
inflammatory
- MeSH:
Animals;
Arthritis;
Arthritis, Experimental;
Collagenases;
Humans;
New Zealand;
Plants, Medicinal;
Rabbits;
Tissue Inhibitor of Metalloproteinase-2;
Tumor Necrosis Factor-alpha
- From:The Korean Journal of Nutrition
2012;45(5):437-442
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was is to investigate the arthritis treatment and prevention of the effects the herbral administration to experimental animals induces arthritis 4 weeks for medicinal herbs (Scutellaria baicalensis Georgi, Acanthopanacis cortex, Achyranthis Radix). To investigate the prevention of histopathological examination and molecular biological examinations for arthritis improvement in vivo New Zealand, white rabbits were divided into a normal (Normal, n = 7), or a collagen-induced arthritis (CIA, n = 7), or a collagenase injection and medicinal herbs (SAA, n = 7). It was confirmed that induced arthritis was treated with Gross examination, and the measurement of average arthritis index (MAI) and improved arthritis by medicinal herbs. TNF-alpha and IL-1beta were significantly increased in the CIA and SAA groups, compared to the normal group (p < 0.05). MMP-1 and TIMP-2 were significantly increased in the CIA, compared to the other groups (p < 0.05). MMP-1 and TIMP-2 were significantly decreased in the SAA group, compared to the CIA group (p < 0.05). As a result, Herbal administration used in this study might be able to help in the treatment of arthritis induced by inflammatory and immunosuppressive effects, that which can be expected.
