Results of Endoscopic Transnasal Transsphenoidal Treatment of Prolactin Secreting Pituitary Adenoma.
- Author:
Chang Hoon LEE
1
;
Soo Whan KIM
;
Jun Myung KANG
;
Do Jin HYUN
;
Chang Hyun YOON
;
Jin Hee CHO
Author Information
1. Department of Otolaryngology-HNS, Collage of Medicine, The Catholic University of Korea, Seoul, Korea. entcho@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Endoscope;
Prolactin;
Pituitary adenoma
- MeSH:
Dopamine Agonists;
Drug Resistance;
Endoscopes;
Humans;
Medical Records;
Pituitary Neoplasms;
Prolactin;
Prolactinoma;
Retrospective Studies
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2008;51(5):429-434
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The endoscopic transnasal transsphenoidal approach is a common approach for pituitary tumor. The objectives of our study is to report indication, efficacy, safety and endocrine result of endoscopic transnasal transsphenoidal surgery in patients with prolactin secreting pituitary adenoma. SUBJECTS AND METHOD: We retrospectively reviewed the medical records of 10 patients who had received endoscopic transnasal transsphenoidal pituitary surgery of prolactin secreting pituitary adenoma. RESULTS: Three patients were resistant and intolerant in medical therapy. Visual symptoms were developed in 8 patients. Postoperatively, 4 patients (40%) achieved normalization of prolactin and relief of symptoms from endoscopic surgery alone. Four of the remaining 6 patients achieved postoperative normalization of prolactin with medication. Visual symptom was improved in all patients. One patient had postoperative diabetes insipidus. CONCLUSION: We believe that the endoscopic method is a safe, hardly invasive and efficient surgical technique in prolactinoma. Medical treatment with dopamine agonist drugs is the mainstay of treatment and endoscopic surgery will be used in cases of drug resistance, intolerance and development of acute visual symptom, we may offer endoscopic surgery as a viable treatment option.
