Regulation of Mucin Exocytosis in Airway Secretory Cells.
10.3342/kjorl-hns.2013.56.3.123
- Author:
Jeong Hong KIM
1
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Jeju National University School of Medicine, Jeju, Korea. sevent70@hanmail.net
- Publication Type:Review
- Keywords:
Airway secretory cells;
Exocytosis;
Mucin;
Regulated mucin secretion
- MeSH:
Asthma;
Cell Membrane;
Cytoplasm;
Epithelium;
Exocytosis;
Mucins;
Proteins;
Pulmonary Disease, Chronic Obstructive;
Respiratory System;
Rhinitis;
Secretory Vesicles
- From:Korean Journal of Otolaryngology - Head and Neck Surgery
2013;56(3):123-130
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mucin secretion in the airway epithelium acts as an essential barrier process that protects the upper respiratory tract from inhaled particles, environmental pathogens and toxicants. However, dysregulated mucin secretion contributes to pathophysiologic conditions such as rhinitis, asthma, and chronic obstructive pulmonary disease etc. The study on mucin hypersecretion has long been worked, but the exact molecular composition and mechanism for exocytic machinery remain mostly to be elucidated. The regulated mucin secretion, highly coordinated process, is mediated by the cooperative interaction of several proteins existing in the secretory granule, cytoplasm, and plasma membrane. This review provides the information on molecular components of the core exocytic machinery and their functional roles for mucin exocytosis in airway secretory cells.
