The Effect of BF-7 on the Ischemia-induced Learning and Memory Deficits.
- Author:
Jun Young LEE
1
;
Sang Hyung LEE
;
Jung Jun SUNG
;
Eui Tae KIM
;
Hye Jin CHO
;
Kyung Hwan KIM
;
Yong Koo KANG
;
Sung Su KIM
;
Oh Sang KWON
;
Won Bok LEE
Author Information
1. Department of Neurosychiatry, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Learning and memory;
BF-7;
Ischemia;
8-arm radial maze test;
Rey Complex Figure Test
- MeSH:
Animals;
Brain;
Dementia;
Hippocampus;
Infarction, Middle Cerebral Artery;
Ischemia;
Learning*;
Memory Disorders*;
Memory*;
Neurons;
Rats
- From:Korean Journal of Anatomy
2005;38(2):181-188
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Abnormal blood supply to brain, such as ischemia induce neuronal damages, possibly leading to dementia. Such damages should be attenuated by neuroprotective materials which make neurons tolerable against limited blood supply or reinforce of blood. For the animal study, transient middle cerebral artery occlusion was operated with SD rat. To check whether BF-7 attenuated the ischemic damage, BF-7 (10 mg/kg) was oral treated for 7 days once a day. To evaluate the learning and memory of the rat, 8-arm maze test was conducted. For clinical study, Rey Complex Figure Test (RCFT) was used with control group (32 person), 200 mg treated group (33 person) and 400 mg treated group (34 person). Treatment of BF-7 greatly reduced the infarct size. Also the neuronal damages in the hippocampus were significantly diminished. Furthermore, The memory impairment by ischemia was recovered. The clinical test showed that BF-7 greatly enhanced the brain function recognizing and memorizing complex two dimensional figures. Our results implicated that BF-7 plays a positive roles on protecting brain and enhancing brain unction clinically.
