Serum Preadipocyte Factor 1 Levels Are Not Associated with Bone Mineral Density among Healthy Postmenopausal Korean Women.
10.3803/EnM.2017.32.1.124
- Author:
Hoon Sung CHOI
1
;
Sang Wook KIM
;
Eun Hee CHO
Author Information
1. Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea. ehcho@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
Preadipocyte factor 1;
Postmenopausal women;
Bone density;
Osteoporosis
- MeSH:
Adipocytes;
Anorexia Nervosa;
Body Mass Index;
Bone Density*;
Female;
Femur Neck;
Hematologic Tests;
Hip;
Humans;
Menopause;
Mesenchymal Stromal Cells;
Multivariate Analysis;
Osteoblasts;
Osteoporosis;
Osteoporotic Fractures;
Retrospective Studies;
Spine
- From:Endocrinology and Metabolism
2017;32(1):124-128
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Multipotent mesenchymal stem cells can differentiate into adipocytes or osteoblasts through closely regulated lineage-control processes. However, adipocyte precursor cells release preadipocyte factor 1 (Pref-1), which inhibits the differentiation of mesenchymal stem cells into mature adipocytes and osteoblasts. Previous studies have also reported an inverse association between Pref-1 levels and bone mineral density (BMD) among patients with anorexia nervosa. METHODS: In this retrospective study, we examined the correlations between Pref-1 levels and BMD among 124 healthy postmenopausal women (>50 years old). The patients had provided information regarding their clinical characteristics, and underwent blood testing and serum Pref-1 testing. RESULTS: The subjects' mean age was 59.9±7.1 years and the median time since menopause onset was 9.1 years. A history of osteoporotic fracture was identified in 23 subjects (19%). Serum Pref-1 levels were not significantly correlated with BMD values at the lumbar spine (R²=0.038, P=0.109), femur neck (R²=0.017, P=0.869), and total hip (R²=0.041, P=0.09), and multivariate analyses with adjustment for age and body mass index also did not detect any significant correlations. Subgroup analyses according to a history of fracture also did not detect significant associations between Pref-1 levels and BMD values. CONCLUSION: In our study population, it does not appear that serum Pref-1 levels are significantly associated with BMD values and osteoporosis.
