Current research situation of thyroid-associated ophthalmopathy and gene polymorphism

VernacularTitle:甲状腺相关眼病与相关基因多态性研究进展
Author: Cui-hong, LIU
Publication Type:Journal Article
Keywords: Thyroid-associated ophthalmopathy; Gene/polymorphism; Genetic/ susceptibility; Cytokine
From: Chinese Journal of Experimental Ophthalmology 2013;32(11):1089-1093
CountryChina
Language:Chinese
Abstract: Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease,and the pathogenesis of TAO is still unclear at present,so it is difficult to take proper prevention and treatment.TAO is a polygenic disease,it is a result of both genetic and environmental factors.Now a large number of researchers showed genetic predisposition of TAO,such as associated genes about cytokine (CK),human leukocyte antigen DR gene (HLA-DR),uridine diphosphate glucose phosphate dehydrogenase gene (UGDH),parathyroid hormone-like hormone gene (PTHLH),human beta defensin-2 gene (HBD-2),cytotoxic T lymphocyte associated antigen-4 gene (CTLA4),cluster of defferentiation 86 gene (CD86) and CD103 gene,cardiac calsequestrin-2 gene (CASQ-2),Toll-like receptor-9 gene (TLR-9),peroxisome proliferation factor receptorγ activation gene (PPAR-γ2),hyaluronan synthase gene (HAS),hyaluronidase gene (HYAL),etc.This review summarizes the corresponding associations respectively based on specific genetic research,so as to have a system understanding to TAO susceptibility genes.