Peripheral T-cell lymphoma with hypodiploidy 43, XY, - 6, -8, -10 in a 64-year-old male: A case report
- Author:
Christian A Gallardo
;
Jesus A Relos
- Publication Type:Case Reports
- From:
Philippine Journal of Internal Medicine
2011;49(2):94-99
- CountryPhilippines
- Language:English
-
Abstract:
Clinical Presentation: A 64-year-old male presented with fever, cervical lymph adenopathy with palpable left axillary lymph node and altered sensorium, impaired concentration and attention span. Laboratory Work-up: Blood culture, Urine culture, CSF analysis were unremarkable so as AFB, GS/ CS and India Ink examination of CSF. CSF cell cytology revealed no malignant cell. Further investigation revealed non-reactive for VDRL, HIV1 and HIV2, and Herplex simplex I and II. Bone Scintigraphy revealed increased osteoblastic activity in the shoulders, elbows, knees and feet most likely degenerative changes. Chest CT scan revealed granuloma at left upper lobe; bilateral pleural effusion, more on the left and axillary lymphadenopathies. Abdominal CT scan revealed hepatomegaly, paraortic and paracaval lymphadenopathies, gastric wall thickening, degenerative changes at lumbar spine and bony changes in the sacrum, may be due to degenerative vs hematologic disorder. Further workup showed nodular aggregated of lymphoid cells. Immunochemistry revealed positive for LCA, CD43, CD3, and CD45RO and negative for CD6, CD20 and MPO clinically correlated as Peripheral T Cell Lymphoma. Cytogenetic studies later revealed Hypoploidy 43XY -6, -8,-10. Diagnosis: Peripheral T-Cell Lymphoma Treatment/Outcome: Patient underwent six cycles of cyclophosphamide, hydroxydaunomycin, oncovin, and prednisone (CHOP) therapy with remission
