Molecular typing and antibiotic resistance patterns of methicillin-resistant Staphylococcus aureus isolates from clinical samples in Malaysia: An update
- Author:
Alreshidi, M.A.
- Publication Type:Journal Article
- From:Tropical Biomedicine
2017;34(1):1-6
- CountryMalaysia
- Language:English
-
Abstract:
A total of 120 non-consecutive MRSA isolates were obtained from hospitalized
patients at Hospital Kuala Lumpur, Malaysia. All isolates were subjected to antimicrobial
susceptibility tests and genotyping based on staphylococcal cassette chromosome
mec(SCCmec), Staphylococcus aureus protein A typing (spa) and multilocus sequence typing
(MLST). Vast majority of MRSA isolates were resistant to more than three classes of antibiotics.
Five antibiotic resistance profiles were observed among the MRSA isolates. All isolates
tested were still susceptible to vancomycin. Genotyping revealed isolates are highly clonal,
where all MRSA belonged to the predominant Asian clone ST239 comprising 4 spa types. Spa
typing revealed four different spa types. Continuous monitoring and effective therapeutic
options for Asian MRSA clone is recommended.
- Full text:P020170529354293083451.pdf
