Description of high rates of unapparent and simultaneous multiple dengue virus infection in a Colombian jungle settlement
- Author:
Castellanos, J.E., Coronel-Ruiz, C., Parra-Alvarez, S., Castilla, M.G., Calvo, E.P., and Velandia-Romero, M.L.
- Publication Type:Journal Article
- From:Tropical Biomedicine
2016;33(2):375-382
- CountryMalaysia
- Language:English
-
Abstract:
Dengue disease statistics is mainly based on consulting patients with febrile
illness, but misdiagnosed and asymptomatic cases are important to measure dengue
epidemiology in endemic areas. The main objective of this work was to determine the
prevalence of IgM and IgG antibodies or NS1 antigen and viral RNA in a group of healthy
volunteers from an isolated village in Colombian Chocó rain forest. It found 51.7% of virologically
PCR confirmed asymptomatic cases, despite low IgM seroprevalence. It was confirmed that
all four serotypes are in the circulation and in 17.2% of individuals it detected natural coinfections
of two or three different serotypes simultaneously. This is the first report in Colombia
evaluating viremia in asymptomatic volunteers. These findings pose a big concern about the
transmission of dengue virus by asymptomatic individuals because they can spread the virus
without take appropriate control measures.
- Full text:P020160901595604610042.pdf
