Effects of vitamin E administration on Plasmodium berghei induced pathological changes and oxidative stress in mice
- Author:
Ibrahim, M.A.
;
Zuwahu, M.M.B.
;
Isah, M.B.
;
Jatau, I.D.
;
Aliyu, A.B.
;
Umar, I.A.
- Publication Type:Journal Article
- From:Tropical Biomedicine
2012;29(1):98-106
- CountryMalaysia
- Language:English
-
Abstract:
Abstract. The effects of daily intraperitoneal doses of 1000 i.u/kg body weight of vitamin E
on the course of Plasmodium berghei NK 65 infection and the parasite-induced anemia as
well as alterations in the relative weight of some selected organs and antioxidant status in
mice were investigated. The number of parasitized red cells were not initially affected by the
vitamin administration but were persistently lowered after 11th day post infection to the
termination of the experiment. The P. berghei infection was found to induce anemia, significantly
(P<0.05) increased the relative weight of liver, spleen and kidney but significantly decreased
(P<0.05) the relative brain weight. However, all the parasite-induced changes in these
parameters were significantly (P<0.05) ameliorated by the vitamin administration. Furthermore,
malonydialdehyde concentration in the serum, liver and brain of infected animals was
significantly (P<0.05) increased whereas superoxide dismutase and catalase activities were
significantly (P<0.05) decreased by the infection. But vitamin E administration was found to,
a significant degree (P<0.05), reversed the disease-induced alterations in these oxidative
stress markers. It was concluded that vitamin E at the dose and route used prevented P.
berghei induced anemia as well as alterations in relative organ weight and antioxidant status
in mice
- Full text:W020150618348796348317.pdf
