Treatment outcome of Paederus dermatitis due to rove beetles (Coleoptera: Staphylinidae) on guinea pigs
- Author:
Fakoorziba, M.R.
;
Eghbal, F.
;
Azizi, K.
;
Moemenbellah-Fard, M.D.*
- Publication Type:Journal Article
- From:Tropical Biomedicine
2011;28(2):418-424
- CountryMalaysia
- Language:English
-
Abstract:
Linear dermatitis (or dermatitis linearis, DL) is a skin blistering inflammatory
lesion caused by exposure to the pederin toxin from rove beetles. Although it is prevalent
in many countries of the Middle East region, this is not a notifiable disease. In recent
years, a number of clinical symptoms outbreaks of DL has been reported from a few
neighboring countries of Iran, but no report of experimental treatment among small
laboratory rodents is known. This is a prerequisite to ascertain the nature of the best
treatment strategy in cases of infestation with these beetles, as it occurs among local
settlers during hot seasons in certain parts of the southern Iranian province of Fars.
Live Paederus beetles were collected, identified to species level, sexed apart and partly
processed to obtain their hemolymph toxin pederin in ethanol for dermal application on
guinea pigs. Two Paederus species were found. Paederus ilsae (Bernhauer) (Coleoptera:
Staphylinidae) was more abundant than P. iliensis (Coiffait). Recovery from DL due to
live P. ilsae beetles was quicker and less complex than that of pederin in ethanol on
guinea pigs. The application of potassium permanganate with calamine to heal DL was
also more effective than fluocinolone treatment. This topical corticosteroid is thus
considered less able to avert the cytotoxic action of pederin on the skin of guinea pigs
than the antipruritic and cleansing agents. It seems likely that fluocinolone has certain
effects which delays the recovery period for the treated skin.
- Full text:W020150615377704034589.pdf
