Toxicological properties of several medicinal plants from the Himalayas (India) against vectors of malaria, filariasis and dengue
- Author:
Alam, M.F.*
;
Mohammed M. Safhi
;
Chopra, A.K.
;
Dua, V.K.
- Publication Type:Journal Article
- From:Tropical Biomedicine
2011;28(2):343-350
- CountryMalaysia
- Language:English
-
Abstract:
The leaves of five plants namely Nyctanthes arbortistis (Oleaceae), Catharanthus
roseus (Apocynaceae), Boenininghusenia albiflora (Rutaceae), Valeriana hardwickii
(Valerianaceae) and Eupatorium odoratum (Asteraceae) were selected for the first time
from the Garhwal region of north west Himalaya to investigation its toxicological properties
against mosquito vectors of malaria, filariasis and dengue. In a laboratory study, using different
polarity solvents (petroleum ether, chloroform and methanol) were tested against important
larvae of malaria, filariasis and dengue vectors in India. It was observed that petroleum ether
fraction of all selected plant possess good larvicidal properties than other solvent fraction.
The LC50 values of isolates from Nyctanthes arbortistis (HAR-1), C. roseus (CAT-1), B. albiflora
(BOA-1), V. hardwickii (SUG-1) and E. odoratum (EUP-1) against Anopheles stephensi were
185 ppm, 150 ppm, 105 ppm, 225 ppm and 135 ppm, respectively. The results therefore
suggest that the fraction code BOA-1 has excellent larvicidal properties and could be
incorporated as botanical insecticides against mosquito vectors with high safety to nontarget
organisms. The same fraction was tested against adult vectors of malaria, filariasis
and dengue, but no mortality was observed.
- Full text:W020150615374342315995.pdf
