Hepatitis B virus (HBV) genotypes in a group of Sri Lankan patients with chronic infection
- Author:
Manamperi, A.*
;
Gunawardene, N.S.
;
Wellawatta, C.
;
Abeyewickreme, W.,
;
de Silva, H.J.
- Publication Type:Journal Article
- From:Tropical Biomedicine
2011;28(2):320-324
- CountryMalaysia
- Language:English
-
Abstract:
Hepatitis B infection causes a wide spectrum of liver diseases. Previous analyses
of hepatitis B virus (HBV) genome have revealed eight HBV genotypes (A-H), with distinct
geographical distribution worldwide. The epidemiology of HBV genotypes and their
implications for natural history of disease progression and response to anti viral therapy have
been increasingly recognized. This study was undertaken to determine the HBV genotypes in
a group of Sri Lankan patients with chronic infection who presented for investigation prior to
treatment. Genotypes were determined (2007-2009) in 25 patients with evidence of chronic
HBV infection. A genotyping system based on multiplex-nested PCR using type-specific primers
was employed in assigning genotypes A through F. Genotypes G and H were not determined.
Among the 25 patients tested, genotypes B [9 (36%)], C [4 (16%)], D [3 (12%)], A [2 (8%)] and
E [1 (4%)] were detected. There was a relatively high prevalence of mixed infections with
genotypes B+C (3), A+D (1), and B+D (2), which overall constituted 24% of patients. Although
this is a non-representative sample, HBV infections among this group of Sri Lankan patients
were predominantly genotypes B, C and D.
- Full text:W020150615372705124061.pdf
