Tegumental alterations of Fasciola gigantica due to in vitro treatment with Ro-354
- Author:
Soliman, M.I.
;
Taha, H.A.*
- Publication Type:Journal Article
- From:Tropical Biomedicine
2011;28(2):283-292
- CountryMalaysia
- Language:English
-
Abstract:
Triclabendazole is the drug of choice against Fasciola infections in humans and
animals. However, parasite resistance against triclabendazole is spreading in veterinary
field, and there are no drugs of comparable activity currently available for the treatment and
control of fascioliasis. The efficacy of a new rhodanine derivative Ro-354 against adult
Fasciola gigantica in vitro was investigated. One hour post incubation, scanning and
transmission electron microscopic examination revealed an evident disruption of the tegument
of F. gigantica as blebbing, swelling and furrowing. Moreover, an increase in severity of
tegumental damage as sloughing and absence of spines was observed. In conclusion, Ro-354
shows potent activity against F. gigantica in vitro, and, the authors recommend carrying out
more studies to detect its efficacy in vivo.
- Full text:W020150615365276064631.pdf
