Application of PET and SPECT in epilepsy
- Author:
Yotin Chinvarun
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(s1):23-25
- CountryMalaysia
- Language:English
-
Abstract:
PET and SPECT are valuable clinical tools in the management of patients with medically resistant,
partial epilepsy who are under evaluation for surgical treatment. The value of PET for localization of
seizure activity has been fi rmly established for patients with temporal lobe epilepsy and extratemporal
lobe epilepsy. It is a very useful test partly because it is non-invasive. The localizing value of ictal
SPECT is based on cerebral metabolic and perfusion coupling. Ictal hyperperfusion is used to localize
the epileptogenic zone noninvasively, and is particularly useful in MRI- negative partial epilepsy and
focal cortical dysplasia. Use of subtraction ictal SPECT coregistered with MRI (SISCOM) improves
localization area of hyperperfusion. However, ictal SPECT should be interpreted in the context of
full presurgical evaluation
- Full text:P020150706595123920999.pdf
