Animal models of early life seizures and epilepsies
- Author:
Marine Jequier Gygax
;
Solomon L. Moshé
- Publication Type:Journal Article
- From:Neurology Asia
2013;18(s1):5-7
- CountryMalaysia
- Language:English
-
Abstract:
Epilepsy can occur throughout the human life span, with peaks during early life and senescense/ageing.
During development, epilepsy is often but not always diagnosed in association with cognitive and
behavioral impairment, which may be the result of the underlying etiology and/or the consequences
of epilepsy and treatments as factors of age and sex. Despite evolutionary and biological differences
between rodent and human brain development, the possibility to model early life epilepsy and seizures
in mice and rats helped the understanding of numerous factors involved in seizures pathophysiology:
neurotransmitter maturation, inhibitory and excitatory pathways imbalance, genetic and epigenetic
infl uences and the association between epileptic activity and learning defi cits. Modeling early life
epilepsies will improve the validity and reliability of translational studies in the search of the underlying
neurobiological pathways and allow for identifi cation and selection of better treatments.
- Full text:P020150706589802351243.pdf
