Role of ROS in Aβ42 mediated cell surface P-selectin expression and actin polymerization
- Author:
Andrey Tsoy
;
Tamara Shalakhmetova
;
Bauyrzhan Umbayev
;
Sholpan Askarova
- Publication Type:Journal Article
- From:Neurology Asia
2014;19(3):309-316
- CountryMalaysia
- Language:English
-
Abstract:
P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation.
In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the
development and progression of Alzhemer’s disease. In this study we have evaluated the effects of
Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3).
Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted
actin polymerization, and these events were correlated with increased reactive oxygen species (ROS)
generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent
an important physiological trigger of the microvascular inflammation in Alzheimer disease.
- Full text:P020150630525782578317.pdf
