The expression of Fascin-1 in colorectal cancer and its clinical significance
10.3969/j.issn.1671-8348.2016.11.023
- VernacularTitle:Fascin-1蛋白在结直肠癌中的表达及其临床意义
- Author:
Huawei MIAO
- Publication Type:Journal Article
- Keywords:
Fascin-1;
colorectal neoplasms;
immunohistochemistry;
long-term survival time
- From:
Chongqing Medicine
2016;45(11):1519-1521,1525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Fascin‐1 in colorectal cancer (CRC) and its clinical significance .Meth‐ods Immunohistochemistry MaxVision method was adopted to detect the protein expression of Fascin‐1 in 87 CRC tissues and 28 para‐cancer tissues ,and analyzed the expressions of them and the relations to clinicopathologic characteristics .Kaplan‐Meier plots and Cox proportional hazards regression model were used to analyze the prognostic value of Fascin‐1 expression .Results The posi‐tive rates of Fascin‐1 expression in CRC tissues and para‐cancer tissues were 43 .7% (38/87) and 7 .1% (2/28) respectively ,with significant difference (P<0 .05) .Fascin‐1 expression was correlated with age ,TNM staging ,regional lymph node metastasis and distant metastasis ,with significant difference (P<0 .05) ,whereas it was not correlated with gender ,tumor location ,pathologic dif‐ferentiation and pathology type ,with no statistical difference(P>0 .05) .In the Kaplan‐Meier analysis ,patients with Fascin‐1 over‐expression had significantly shorter overall survival than those patients with negative Fascin‐1 expression (P=0 .009) .Multivari‐able analysis by Cox regression model further showed that Fascin‐1 over‐expression was a significantly independent predictor of poorer overall survival (HR=2 .087;95% CI:1 .196-3 .642 ,P=0 .010) .Conclusion The expression of Fascin‐1 is high and its re‐lated to the long‐term survival time of patients with CRC .It is an independent prognostic factor for CRC .
